Relationship of Non-HDL Cholesterol, Triglyceride-glucose index and HbA1c in Type 2 Diabetes Mellitus: A Descriptive Crosssectional Study

Abstract

INTRODUCTION: Diabetes is an ongoing epidemic that has been increasing in Nepal. Non-HDLc (Non-high density lipoprotein cholesterol) are considered as strong predictor for cardiovascular risk in diabetes patients. HbA1c level play significant role in evaluating long-term control and complications with cardiovascular events. Many studies showed surrogate markers i.e. triglyceride-glucose index (TyG) and triglyceride/HDLc ratio (TG/HDL-C) could estimate cardiovascular outcome in Type 2 Diabetes patients.

METHOD: This was a descriptive cross-sectional study conducted among 120 diagnosed cases of type 2 diabetes mellitus visited in outpatient department of Internal Medicine and Endocrine at National academy of medical sciences (NAMS), Bir Hospital, Kathmandu, Nepal. Fasting blood samples were collected from the patients, serum lipids were measured and Non-HDLc and TyG index were calculated. Demographic, anthropometric and cardiovascular risk factors related data were collected. Data were entered in Microsoft Excel 2010 and analysis was done by using the Statistical Package for the Social Sciences version 22.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data, and mean and standard deviation for continuous data.

RESULT: Mean age was 53.76±10.12 years. Mean Non-HDLc was 167.51±45.47mg/dl. Mean HbA1c and Uric acid were 8.24±1.37% and 5.6±0.85mg/dl respectively. Non-HDLc showed positive correlation with HbA1c (r=0.183; p=0.045) and Uric acid (r=0.295; p=0.001). However, there is no correlation of Non HDLc with TyG index. Similarly, a positive correlation between TG/HDLc and TyG index (r=0.759;

CONCLUSION: Non-HDLc are considered as strong predictor for cardiovascular risk. Thus Non HDLc has been suggested as a simple way to analyze proatherogenic lipoproteins and it’s also help to predicts the development of cardiovascular risk in diabetes patients.

KEYWORDS: Diabetes Mellitus, Glycated Hemoglobin A, Non-high-density lipoprotein Triglyceride-glucose Index