Comparison of attenuating effects of Lignocaine on Hemodynamic response to laryngoscopy and Intubation with Etomidate induction for Coronary Artery Bypass Graft surgery

Abstract

 Background: Direct laryngoscopy and intubation is invariably associated with hemodynamic changes (Hypertension, tachycardia and arrhythmias) which may be hazardous to patient especially if they have cardiac morbidity. Lignocaine is regularly used to attenuate these changes although the evidence supporting its use is not well established. Moreover, there is scarcity of study regarding usefulness of lignocaine when etomidate, a cardiac stable drugs, is used for induction.

Materials and Methods: Total 104 patients undergoing CABG were randomized in two groups, lignocaine was given in one group, the other received normal saline. In  this double blind controlled clinical trial etomidate induction was performed. Heart rate(HR), Systolic blood pressure(SBP), Diastolic blood pressure(DBP) and mean blood pressure(MBP)collected at 0, 1, 3, 5, and 10 minutes of intubation.

Results: There was no significant difference between the demographic profile between two groups. Our results showed no significant differences between Baseline, SBP, DBP and MBP at 1,3,5 and 10 minutes after laryngoscopy and endotracheal intubation. Baseline HR, HR at 1,3,5 and 10 minutes after laryngoscopy and endotracheal intubation were also not significantly different between the two groups.

Conclusions: Lignocaine has no attenuating effect on hemodynamic response to laryngoscopy and Intubation with
Etomidate induction for CABG surgery