A case-control study on the correlation between the Ovarian Reserve Test and thyroid hormone levels at the Paropakar Maternity & Women’s Hospital

Abstract

ABSTRACT

Introduction: One in every four couples are affected with infertility in the developing countries. The situation of infertility is increasing in Nepal and it needs to be addressed.

Methods: A single-center case control study was conducted at the Paropakar Maternity & Women’s Hospital between April 14^th, 2023 to June 25^th, 2023. A total of 133 patients were enrolled for the study. All patients, between 20-40 years, who had spontaneous menstrual cycles on days 2 or 3 visited the OPD were included in the study. However, the patients who had cases such as endometrosis, ovarian surgery for ovarian cysts and ovarian tumors, under chemotherapy treatment and hormonal treatment, and polycystic ovary syndrome were excluded in the study.

Results: This study aimed to investigate the relationship between ovarian reserve test and thyroid hormone level in women with infertility. Two groups were divided on the basis of the TSH level, control (TSH<4.5) and case (TSH≥4.5). Based on the findings of the study of Pearson’s correlation test, AMH and FT4 were found to be statistically significant and have moderate positive relationships for the case group, which suggests that, with increase in level of AMH, FT4 also tends to increase. In addition, Spearman’s correlation test was used to further explore the non-linear relationship, which helped to establish the positive significant correlation in the control group between AMH and FT3.

Conclusion: Based on the findings of the study of Pearson’s correlation test, AMH and FT4 were found to be statistically significant and have moderate positive relationships.