Correlation of Fine Needle Aspiration Cytology with Histopathological Examination of Thyroid Swellings

Authors

  • Sonika Dhari Shrestha National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal
  • Suman Khatri National medical college, Birgunj, Parsa, Nepal
  • Ravibhusan Suwal National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal
  • Dipendra Gautam National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal

DOI:

https://doi.org/10.56974/pmjn.128

Keywords:

Fine needle aspiration cytology, histopathological examination, thyroid swellings

Abstract

Introduction: Fine Needle Aspiration Cytology (FNAC) is considered as a simple, minimally invasive, cost effective, readily repeated and quick to perform procedure in the outpatient department with excellent patient compliance. High sensitivity and specificity of FNAC has made it as an initial diagnostic in thyroid swellings. However, it has its own limitation as in cases of lymphoma and follicular adenoma.

Methods: Prospective, observational study including total of 37 patients (7 males and 30 females) with thyroid swellings who presented in department ORL-HNS, National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal were evaluated pre-operatively with FNAC from August 2017 to July 2018 and these findings were compared with histopathology observations following thyroidectomy.

Results: Out of 37 patients evaluated, 16 (43.20%) were found to have malignancy on histopathological examination (HPE). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of FNAC was 61.5%, 94.4%, 88.9%, 77.3% and 80.6% respectively.

Conclusion: We can conclude that FNAC is a simple, safe and cost-effective diagnostic modality in the investigation of thyroid swellings with high specificity, PPV and accuracy.

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Published

2024-02-16

Issue

Section

Orginal Articles