Clinical Profile, Risk Factors and Hospital Mortality of Sepsis In Cirrhosis

Jaishi B*, Prajapat S**, Shrerstha SL***, Karki ND****


INTRODUCTION: Sepsis is common in cirrhotic patent. But studies regarding it are very few in this part of the world. So the purpose of this study was to know incidence, clinical profile, risk factors and outcome of sepsis in cirrhosis.

METHOD: The study was designed as a hospital-based analytical, cross-sectional study. It was conducted in the Liver unit at Bir Hospital, Nepal.144 patents of cirrhosis who fulfilled the inclusion criteria between Baisak,2072 to Chaitra,2072 were chosen for the study. Non-cirrhotic cases, not fulfilling criteria and those who refused to give consent, were excluded. Patents of cirrhosis with sepsis and without sepsis who were treated in the hospital were enrolled in this study.

RESULT: Among the study population,61(42%) had sepsis. The male patents were109 (76%) and 35(24%) were female. In septic patients, 25(41%) had SBP, 17(28%) had Urinary Tract Infection (UTI), 14(23%) had pneumonia, 5(8%) had a miscellaneous infection. Low serum albumin level was in 78 and 59(p=0.71), CPS-C was in 42 and 40 (p=0.07), previous history of infection was in 1and 2(p=.78), upper gastrointestinal bleeding (UGIB) was in 10 and 10(p=.45) and hyponatremia was 56 and 30 (p=.03) in non septic and septic patients respectively. Among all infected patients,
meropenem was most commonly used antibiotics (26%).Mortality was 17(28%) in septic patent and 7(5%) in non septic patent (p=0.002).

CONCLUSION: The incidence and mortality of sepsis was high in our study. Clinical profile of sepsis was similar to other parts of world. The risk factors associated with sepsis were hyponatremia and CPS-C.

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