Intraoperative Lignocaine Infusion for Prevention of Post Operative Pain after Cholecystectomy
Abstract
Introduction: Post operative pain is the major concern in surgery because it affects multiple systems. It induces physiological, immunological, and psychological changes. Intravenous lignocaine can be used as multimodal therapy to pain control.
Methods: This was a randomized double blind study in 50 patients (8 male, 42 female) for cholecystectomy. Both groups consist of 25 patients. Group one received 1.5mg/kg bolus lignocaine followed by 2mg/kg/h infusion. Group two received saline. In both groups induction, maintenance, type of surgery and duration of anesthesia were similar. Pain in PACU was assessed with VRS score. Intramuscular pethidine was given for pain control as required.
Results: VRS score at 24hrs in PACU was significantly less in lignocaine group than in control group at rest, on coughing and in walking. Similarly the total pethidine requirement in PACU was significantly less in lignocaine group (108±27.68 mg) than control group (160±35.35), p value < .0001.
Methods: This was a randomized double blind study in 50 patients (8 male, 42 female) for cholecystectomy. Both groups consist of 25 patients. Group one received 1.5mg/kg bolus lignocaine followed by 2mg/kg/h infusion. Group two received saline. In both groups induction, maintenance, type of surgery and duration of anesthesia were similar. Pain in PACU was assessed with VRS score. Intramuscular pethidine was given for pain control as required.
Results: VRS score at 24hrs in PACU was significantly less in lignocaine group than in control group at rest, on coughing and in walking. Similarly the total pethidine requirement in PACU was significantly less in lignocaine group (108±27.68 mg) than control group (160±35.35), p value < .0001.